Berberine Hydrochloride: Premium Quality from Natural Sources

Wholesale Berberine HCL Powder

Berberine HCL, also known as berberine hydrochloride, is a quaternary ammonium alkaloid isolated from Coptis chinensis. Berberine is usually found in the roots, rhizomes, stems, and bark. It can be also synthesized in an artificial method. It is used as raw material to make preparations.

Berberine is a yellow powder with a bitter taste. Berberine dissolves in hot water, slightly soluble in water or ethanol, and in chloroform Very slightly soluble, insoluble in ether. 

Many studies show that Berberine hydrochloride can significantly reduce blood sugar levels. Berberine may help you lose weight. Berberine can lower cholesterol and may reduce your risk of heart disease. Berberine HCL powder has the same health benefits as berberine.

JIUYUAN BIOTECH's Berberine Hydrochloride is meticulously produced using premium Berberis aristata and Berberis spp. (Three-Needle Berberis) as raw materials. Our advanced extraction processes ensure the product's purity and quality. Both Berberis aristata and Three-Needle Berberis are excellent natural sources of berberine, with their roots and stems rich in high concentrations of the active compound.

We adhere to stringent quality control procedures throughout the entire production process, from raw material procurement and extraction to purification and finished product testing. This ensures that every batch of Berberine Hydrochloride meets international standards, with a purity of ≥98%.

Our product is a light yellow crystalline powder, exhibiting good solubility and stability. It is suitable for use in pharmaceuticals, health supplements, and dietary supplements. We offer customized packaging to meet diverse procurement needs and are committed to prompt delivery and comprehensive after-sales service.

Choose our Berberine Hydrochloride to infuse your products with natural, effective, and reliable quality assurance.

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Berberine Hydrochloride: A Multifaceted Approach to Health and Wellness

Berberine Hydrochloride offers a wide range of potential health benefits, supported by scientific research:

Antimicrobial and Anti-inflammatory Action:

Berberine Hydrochloride exhibits inhibitory effects against various bacteria, including Shigella, E. coli, and Staphylococcus aureus, as well as protozoa like Amoeba. This makes it a valuable agent in treating intestinal infections and bacillary dysentery. Furthermore, its anti-inflammatory properties contribute to reducing systemic inflammation.

Blood Sugar Regulation:

Berberine Hydrochloride enhances insulin sensitivity and lowers blood sugar levels, demonstrating significant hypoglycemic effects in individuals with type 2 diabetes.

Cardiovascular Health:

This compound improves cholesterol profiles by reducing LDL-C and triglycerides while increasing HDL-C levels. These actions collectively promote cardiovascular health.

Gut Health:

Berberine Hydrochloride aids in balancing the gut microbiota, alleviating gastrointestinal discomfort and supporting a healthy digestive system.

Anti-tumor Activity:

Studies have shown that Berberine Hydrochloride possesses in vitro and in vivo anti-tumor activity, including the ability to induce cell differentiation.

Immune Support:

Berberine Hydrochloride strengthens the immune system, helping the body defend against pathogens, particularly during periods of stress or seasonal changes.

Additional Benefits:

Beyond the above, Berberine Hydrochloride also exhibits antioxidant and antiarrhythmic effects.

Berberine HCl: A Versatile Compound with Diverse Applications

Berberine HCl, a naturally occurring compound with a wide range of biological activities, finds applications across various industries, including pharmaceuticals, health supplements, food additives, and cosmetics. Here's a breakdown of its primary applications and specific uses:

1. Pharmaceutical Applications:

Berberine HCl is most widely used in the pharmaceutical field, primarily for the following:

Blood Sugar Regulation: Berberine HCl lowers blood sugar through multiple mechanisms, including increasing insulin sensitivity, inhibiting hepatic gluconeogenesis, and promoting glycogen synthesis. It's widely used as an adjunct therapy for type 2 diabetes, demonstrating significant efficacy with minimal side effects.

Cardiovascular Health: Studies show Berberine HCl can regulate blood lipid levels, lowering LDL-C and triglycerides while increasing HDL-C, thus reducing the risk of cardiovascular diseases.

Antimicrobial and Anti-inflammatory: Berberine HCl inhibits various bacteria, fungi, and viruses, particularly intestinal pathogens like Shigella and E. coli. Its anti-inflammatory properties are also used to treat inflammatory conditions.

Anti-tumor Activity: Berberine HCl exhibits anti-tumor activity in vitro and in vivo, inducing apoptosis and inhibiting proliferation of cancer cells.

Other Conditions: Berberine HCl is also used to manage metabolic disorders like obesity, polycystic ovary syndrome (PCOS), and non-alcoholic fatty liver disease (NAFLD).

2. Health Supplement Applications:

Due to its numerous health benefits, Berberine HCl is widely used in health supplements:

Blood Sugar Management: As a dietary supplement, it helps maintain healthy blood sugar levels, especially for pre-diabetic individuals or those needing blood sugar control.

Cardiovascular Support: By regulating blood lipids and improving cardiovascular function, it contributes to cardiovascular health.

Immune Support: Its antimicrobial and anti-inflammatory properties enhance the immune system, helping the body fight off pathogens.

Gut Health: Berberine HCl regulates gut microbiota, promoting gut health and relieving constipation and diarrhea.

3. Food Additive Applications:

Berberine HCl's natural origin and antimicrobial properties make it a suitable food additive:

Preservative: Its natural antibacterial action can preserve food and extend shelf life.

Functional Food: Some functional foods incorporate Berberine HCl for its health benefits, such as blood sugar regulation and cardiovascular improvement.

4. Cosmetic Applications:

Berberine HCl's applications in cosmetics are mainly due to its antioxidant and whitening effects:

Whitening: It inhibits tyrosinase activity, reducing melanin production and thus used in whitening and spot-fading products.

Antioxidant: Its antioxidant properties protect skin from free radical damage and delay aging.

5. Other Applications:

Feed Additive: In animal husbandry, it's added to feed to improve immunity and growth performance.

Research: Due to its diverse biological activities, it's widely used in biomedical research as a research tool or experimental material.

Conclusion:

Berberine HCl's diverse biological activities and broad health benefits make it an important ingredient in various fields like pharmaceuticals, health supplements, food, and cosmetics. Its applications are extensive, and ongoing research continually uncovers new potential uses. However, dosage and potential side effects should be considered, especially in pharmaceuticals and health supplements. Consulting professionals is recommended for proper guidance.

Reference:

1: Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 2008;57(5):712-717.

2: Zhang H, Wei J, Xue R, et al. Berberine lowers blood glucose by activating AMPK in insulin-resistant type 2 diabetic mice. Mol Cell Biochem. 2007;306(1-2):249-256.

3: Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab. 2008;93(7):2506-2511.

4: Li Y, Yao J, Han C, et al. Antioxidant activity and protective effect of berberine on acute lung injury in mice. Pharmacol Biochem Behav. 2012;102(2):261-266.

5: Han J, Wu J, Li Y, et al. Berberine induces apoptosis in human hepatocellular carcinoma cells via the mitochondrial pathway. Cancer Lett. 2006;234(1):114-120.

6: Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab. 2008;93(7):2506-2511.

7: Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 2008;57(5):712-717.

8: Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab. 2008;93(7):2506-2511.

9: Li Y, Yao J, Han C, et al. Antioxidant activity and protective effect of berberine on acute lung injury in mice. Pharmacol Biochem Behav. 2012;102(2):261-266.

10: Zhang H, Wei J, Xue R, et al. Berberine lowers blood glucose by activating AMPK in insulin-resistant type 2 diabetic mice. Mol Cell Biochem. 2007;306(1-2):249-256.

11: Li Y, Yao J, Han C, et al. Antioxidant activity and protective effect of berberine on acute lung injury in mice. Pharmacol Biochem Behav. 2012;102(2):261-266.

12: Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab. 2008;93(7):2506-2511.

13: Han J, Wu J, Li Y, et al. Berberine induces apoptosis in human hepatocellular carcinoma cells via the mitochondrial pathway. Cancer Lett. 2006;234(1):114-120.

14: Li Y, Yao J, Han C, et al. Antioxidant activity and protective effect of berberine on acute lung injury in mice. Pharmacol Biochem Behav. 2012;102(2):261-266.

15: Zhang H, Wei J, Xue R, et al. Berberine lowers blood glucose by activating AMPK in insulin-resistant type 2 diabetic mice. Mol Cell Biochem. 2007;306(1-2):249-256.

16: Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 2008;57(5):712-717.